울산과학기술원 (Ulsan National Institute of Science and Technology, UNIST)
생명과학과

Recent papers

Erratum: Mitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding Site (Journal of the American Chemical Society (2021) 143:47 (19684-19696) DOI: 10.1021/jacs.1c07099)
Journal of the American Chemical Society 2022, 144 (4), 2020–0.
Structural basis for mitoguardin-2 mediated lipid transport at ER-mitochondrial membrane contact sites
Nature Communications 2022, 13, 3702–0.
A chemical tool for blue light-inducible proximity photo-crosslinking in live cells
Chemical Science 2022, 13 (4), 955–966.
Augmented ERAD (ER-associated degradation) activity in chondrocytes is necessary for cartilage development and maintenance
Science Advances 2022, 8 (3).
Design and Synthesis of TRAP1 Selective Inhibitors: H-Bonding with Asn171 Residue in TRAP1 Increases Paralog Selectivity
ACS Medicinal Chemistry Letters 2021, 12 (7), 1173–1180.
Mitoquinone Inactivates Mitochondrial Chaperone TRAP1 by Blocking the Client Binding Site
Journal of the American Chemical Society 2021, 143 (47), 19684–19696.
Development of pyrazolo[3,4-d]pyrimidine-6-amine-based TRAP1 inhibitors that demonstrate in vivo anticancer activity in mouse xenograft models
Bioorganic Chemistry 2020, 101.
Discovery of 2-((4-resorcinolyl)-5-aryl-1,2,3-triazol-1-yl)acetates as potent Hsp90 inhibitors with selectivity over TRAP1
Bioorganic and Medicinal Chemistry Letters 2020, 30 (2).
Bright ligand-activatable fluorescent protein for high-quality multicolor live-cell super-resolution microscopy
Nature Communications 2020, 11 (1).
Impaired DNA-binding affinity of novel PAX6 mutations
Scientific Reports 2020, 10 (1).
Quaternary structures of Vac8 differentially regulate the Cvt and PMN pathways
Autophagy 2020, 16 (6), 991–1006.
Rare Variants of Putative Candidate Genes Associated With Sporadic Meniere's Disease in East Asian Population
Frontiers in Neurology 2020, 10.
The structure of human EXD2 reveals a chimeric 3′ to 5′ exonuclease domain that discriminates substrates via metal coordination
Nucleic Acids Research 2019, 47 (13), 7078–7093.
Ergosterol interacts with Sey1p to promote atlastin-mediated endoplasmic reticulum membrane fusion in Saccharomyces cerevisiae
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019, 33 (3), 3590–3600.
Identification of a novel GPR143 mutation in X-linked ocular albinism with marked intrafamilial phenotypic variability
Journal of Genetics 2018, 97 (5), 1479–1484.
Genotype and Phenotype Spectrum of FRMD7-Associated Infantile Nystagmus Syndrome
Investigative Ophthalmology and Visual Science 2018, 59 (7), 3181–3188.
Paralog Specificity Determines Subcellular Distribution, Action Mechanism, and Anticancer Activity of TRAP1 Inhibitors
Journal of Medicinal Chemistry 2017, 60 (17), 7569–7578.
Genetically Encodable Bacterial Flavin Transferase for Fluorogenic Protein Modification in Mammalian Cells
ACS Synthetic Biology 2017, 6 (4), 667–677.
The crystal structure of human Rogdi provides insight into the causes of Kohlschutter-Tönz Syndrome
Scientific Reports 2017, 7 (1).
Molecular mechanisms of atlastin-mediated ER membrane fusion revealed by a FRET-based single-vesicle fusion assay
Scientific Reports 2017, 7 (1).
Rogdi Defines GABAergic Control of a Wake-promoting Dopaminergic Pathway to Sustain Sleep in Drosophila
Scientific Reports 2017, 7 (1).
Structure-guided synthesis of a protein-based fluorescent sensor for alkyl halides
Chemical Communications 2017, 53 (66), 9226–9229.
Mechanistic insight into the nucleus-vacuole junction based on the Vac8p-Nvj1p crystal structure
Proceedings of the National Academy of Sciences of 2017, 114 (23).
Crystal structures of Mmm1 and Mdm12–Mmm1 reveal mechanistic insight into phospholipid trafficking at ER-mitochondria contact sites
Proceedings of the National Academy of Sciences of 2017, 114 (45).
Proximity-directed labeling reveals a new rapamycin-induced heterodimer of FKBP25 and FRB in live cells
ACS Central Science 2016, 2 (8), 506–516.
Crystal structure of SEL1L: Insight into the roles of SLR motifs in ERAD pathway
Scientific Reports 2016, 6.
LPS-induced NFκB enhanceosome requires TonEBP/NFAT5 without DNA binding
Scientific Reports 2016, 6.
Crystal structure of Mdm12 reveals the architecture and dynamic organization of the ERMES complex
EMBO Reports 2016, 17 (12), 1857–1871.
Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP
Journal of the American Chemical Society 2015, 137 (13), 4358–4367.
Crystallization and preliminary X-ray diffraction analysis of the Sel1-like repeats of SEL1L
Acta Crystallographica Section:F Structural Biology Communications 2014, 70, 1624–1627.
Crystallization and preliminary X-ray diffraction analysis of Trap1 complexed with Hsp90 inhibitors
Acta Crystallographica Section:F Structural Biology Communications 2014, 70, 1683–1687.
Structure of Coatomer Cage Proteins and the Relationship among COPI, COPII, and Clathrin Vesicle Coats
Cell 2010, 142 (1), 123–132.
Structure of a peptide:N-glycanase-Rad23 complex: Insight into the deglycosylation for denatured glycoproteins
Proceedings of the National Academy of Sciences of 2005, 102 (26), 9144–9149.
Structural basis for inhibition of the replication licensing factor Cdt1 by geminin
Nature 2004, 430 (7002), 913–917.
Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9-AdoMet
EMBO Journal 2003, 22 (2), 292–303.
Interactions of SV40 large T antigen and other viral proteins with retinoblastoma tumour suppressor
Reviews in Medical Virology 2002, 12 (2), 81–92.
Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor
Genes and Development 2002, 16 (24), 3199–3212.

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