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Recent papers

Egg Microneedle for Transdermal Delivery of Active Liraglutide Advanced Healthcare Materials 2023.

Oral administration of CU06-1004 attenuates vascular permeability and stabilizes neovascularization in retinal vascular diseases European Journal of Pharmacology 2023, 939.

Endothelial PTP4A1 mitigates vascular inflammation via USF1/A20 axis-mediated NF-κB inactivation Cardiovascular Research 2023, 119 (5), 1265–1278.

CU06-1004 alleviates vascular hyperpermeability in a murine model of hereditary angioedema by protecting the endothelium Allergy: European Journal of Allergy and Clinical Immunology 2023.

Efficacy of CU06-1004 via regulation of inflammation and endothelial permeability in LPS-induced acute lung injury Journal of Inflammation (United Kingdom) 2023, 20 (1).

Long-term administration of CU06-1004 ameliorates cerebrovascular aging and BBB injury in aging mouse model Fluids and Barriers of the CNS 2023, 20 (1).

A pipeline to characterize p53 effectors by integrative cistrome and transcriptome analysis in a genetically-defined organoid model Genes and Diseases 2023.

Streamlined DNA-encoded small molecule library screening and validation for the discovery of novel chemotypes targeting BET proteins Molecular Therapy - Nucleic Acids 2023, 32, 637–649.

A TEAD2-Driven Endothelial-Like Program Shapes Basal-Like Differentiation and Metastasis of Pancreatic Cancer Gastroenterology 2023.

Reprogramming anchorage dependency by adherent-to-suspension transition promotes metastatic dissemination Molecular Cancer 2023, 22 (1), 63–0.

IKK-mediated TRAF6 and RIPK1 interaction stifles cell death complex assembly leading to the suppression of TNF-α-induced cell death Cell Death and Differentiation 2023.

Visuomotor anomalies in achiasmatic mice expressing a transfer-defective Vax1 mutant Experimental and Molecular Medicine 2023, 55 (2), 385–400.

Short-term carcinogenicity study of N-methyl-N-nitrosourea in FVB-Trp53 heterozygous mice PLoS ONE 2023, 18 (1 January).

Emphasis on Adipocyte Transformation: Anti-Inflammatory Agents to Prevent the Development of Cancer-Associated Adipocytes Cancers 2023, 15 (2).

Chronic LCMV infection regulates the effector T cell response by inducing the generation of less immunogenic dendritic cells Experimental and Molecular Medicine 2023.

Discovery of highly immunogenic spleen-resident FCGR3 + CD103 + cDC1s differentiated by IL-33-primed ST2 + basophils Cellular and Molecular Immunology 2023.

Protective Efficacy and Immunogenicity of Rv0351/Rv3628 Subunit Vaccine Formulated in Different Adjuvants Against Mycobacterium tuberculosis Infection Immune Network 2023, 23 (2).

KLC3 Regulates Ciliary Trafficking and Cyst Progression in CILK1 Deficiency–Related Polycystic Kidney Disease Journal of the American Society of Nephrology 2022, 33 (9), 1726–1741.

Tissue-specific requirement of sodium channel and clathrin linker 1 (Sclt1) for ciliogenesis during limb development Frontiers in Cell and Developmental Biology 2022, 10.

CU06-1004 modulates the adenosine monophosphate (AMP)-associated protein kinase (AMPK) signaling pathway and inhibits lipogenesis in 3T3-L1 adipocytes and high-fat diet-induced obese mice Life Sciences 2022, 296.

Extract of Moutan radicis cortex and Cinnamomi ramulus ameliorates laser-induced choroidal neovascularization in Brown-Norway rats Phytomedicine 2022, 94.

CU06-1004 enhances vascular integrity and improves cardiac remodeling by suppressing edema and inflammation in myocardial ischemia–reperfusion injury Experimental and Molecular Medicine 2022, 54 (1), 23–34.

REDD1 promotes obesity-induced metabolic dysfunction via atypical NF-κB activation Nature Communications 2022, 13 (1).

DIX domain containing 1 (DIXDC1) modulates VEGFR2 level in vasculatures to regulate embryonic and postnatal retina angiogenesis BMC Biology 2022, 20 (1).

Deletion of ATAD3A inhibits osteogenesis by impairing mitochondria structure and function in pre-osteoblast Developmental Dynamics 2022.

2′–5′ oligoadenylate synthetase‑like 1 (OASL1) protects against atherosclerosis by maintaining endothelial nitric oxide synthase mRNA stability Nature Communications 2022, 13 (1).

OASL1-Mediated Inhibition of Type I IFN Reduces Influenza A Infection-Induced Airway Inflammation by Regulating ILC2s Allergy, Asthma and Immunology Research 2022, 14 (1), 99–116.

Methylation-sensitive high-resolution melting analysis of the USP44 promoter can detect early-stage hepatocellular carcinoma in blood samples BMB Reports 2022, 55 (11), 553–558.

ZNF204P is a stemness-associated oncogenic long non-coding RNA in hepatocellular carcinoma BMB Reports 2022, 55 (6), 281–286.

LCK-Mediated RIPK3 Activation Controls Double-Positive Thymocyte Proliferation and Restrains Thymic Lymphoma by Regulating the PP2A-ERK Axis Advanced Science 2022.

Discovery of indirubin-3′-aminooxy-acetamide derivatives as potent and selective FLT3/D835Y mutant kinase inhibitors for acute myeloid leukemia European Journal of Medicinal Chemistry 2022, 237.

The N-Terminal Domain of Bfa1 Coordinates Mitotic Exit Independent of GAP Activity in Saccharomyces cerevisiae Cells 2022, 11 (14).

Nst1, Densely Associated to P-Body in the Post-Exponential Phases of Saccharomyces cerevisiae, Shows an Intrinsic Potential of Producing Liquid-Like Condensates of P-Body Components in Cells International Journal of Molecular Sciences 2022, 23 (5).

The Multivalent Polyampholyte Domain of Nst1, a P-Body-Associated Saccharomyces cerevisiae Protein, Provides a Platform for Interacting with P-Body Components International Journal of Molecular Sciences 2022, 23 (13).

SOD3 Suppresses the Expression of MMP-1 and Increases the Integrity of Extracellular Matrix in Fibroblasts Antioxidants 2022, 11 (5).

Anti-PTK7 Monoclonal Antibodies Inhibit Angiogenesis by Suppressing PTK7 Function Cancers 2022, 14 (18).

PTK7, a Catalytically Inactive Receptor Tyrosine Kinase, Increases Oncogenic Phenotypes in Xenograft Tumors of Esophageal Squamous Cell Carcinoma KYSE-30 Cells International Journal of Molecular Sciences 2022, 23 (4).

Polyamine Oxidase Expression Is Downregulated by 17β-Estradiol via Estrogen Receptor 2 in Human MCF-7 Breast Cancer Cells International Journal of Molecular Sciences 2022, 23 (14).

Expression of Polyamine Oxidase in Fibroblasts Induces MMP-1 and Decreases the Integrity of Extracellular Matrix International Journal of Molecular Sciences 2022, 23 (18).

Anti-PTK7 Monoclonal Antibodies Exhibit Anti-Tumor Activity at the Cellular Level and in Mouse Xenograft Models of Esophageal Squamous Cell Carcinoma International Journal of Molecular Sciences 2022, 23 (20).

Structural insights into the HBV receptor and bile acid transporter NTCP Nature 2022, 606 (7916), 1027–1031.

Structural and functional identification of the uncharacterized metallo-β-lactamase superfamily protein TW9814 as a phosphodiesterase with unique metal coordination Acta Crystallographica Section D: Structural Biology 2022, 78, 532–541.

Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface PLoS Biology 2022, 20 (8).

Substituted Syndecan-2-Derived Mimetic Peptides Show Improved Antitumor Activity over the Parent Syndecan-2-Derived Peptide International Journal of Molecular Sciences 2022, 23 (11).

Crystal Structures of the Plant Phospholipase A1 Proteins Reveal a Unique Dimerization Domain Molecules 2022, 27 (7).

Cryo-EM structure of the human somatostatin receptor 2 complex with its agonist somatostatin delineates the ligand-binding specificity eLife 2022, 11.

Establishment of a mechanism-based in vitro coculture assay for evaluating the efficacy of immune checkpoint inhibitors Cancer Immunology, Immunotherapy 2022.

The oxidative phosphorylation inhibitor IM156 suppresses B-cell activation by regulating mitochondrial membrane potential and contributes to the mitigation of systemic lupus erythematosus Kidney International 2022.

Viral coinfection promotes tuberculosis immunopathogenesis by type I IFN signaling-dependent impediment of Th1 cell pulmonary influx Nature Communications 2022, 13 (1).

Deletion of PD-1 destabilizes the lineage identity and metabolic fitness of tumor-infiltrating regulatory T cells Nature Immunology 2022.

Gut microbiota of the young ameliorates physical fitness of the aged in mice Microbiome 2022, 10 (1).

Immune Checkpoint Inhibitors in 10 Years: Contribution of Basic Research and Clinical Application in Cancer Immunotherapy Immune Network 2022, 22 (1).

Human Rhinovirus Infection of the Respiratory Tract Affects Sphingolipid Synthesis American Journal of Respiratory Cell and Molecular Biology 2022, 66 (3), 302–311.

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